Patrick Lagüe, professeur agrégé
Pavillon Charles-Eugène-Marchand, local 4255
T. 418 656-2311
F. 418 656-7176
Patrick.Lague@bcm.ulaval.ca
Champs d'intérêts
  • Modélisation moléculaire de molécules d'intérêt biologique
  • Structure et dynamique des protéines et des lipides
  • Interactions entre les protéines et les membranes cellulaires

Publications

La liste complète se trouve sur le site de l'Institut de biologie intégrative et des systèmes.

  • Cardinal, S., Bouchard, C., Barbeau, X ., Lagüe, P. , Voyer, N. (2016) Interfacial supramolecular biomimetic epoxidation catalyzed by cyclic dipeptides. Supramolecular chemistry . Accepted for publication.
  • Ouellet, C., Maltais, R., Ouellet, É., Barbeau, X ., Lagüe, P. , Poirier, D. (2016) Discovery of a sulfamatebased steroid sulfatase inhibitor with intrinsic selective estrogen receptor modulator properties. Eur. J. Med. Chem. 119 :169182.
  • Paz Ramos, A., Lagüe, P ., Lamoureux, G., Lafleur, M. (2016) Effect of Saturated Very LongChain Fatty Acids on the Organization of Lipid Membranes: A Study Combining 2H NMR Spectroscopy and Molecular Dynamics Simulations. J. Phys. Chem. B 120 :69516960.
  • IyombeEngembe, J.P.? Ouellet, D. L.? Barbeau, X .? Rousseau, J.? Chapdelaine, P.? Lagüe , P.? Tremblay, J. P. (2016). Efficient Restoration of the Dystrophin Gene Reading Frame and Protein Structure in DMD Myoblasts Using the CinDel Method. Molecular Therapy Nucleic Acids 5 (1) e283.
  • Vincent, A. T., EmondRheault, J.G., Barbeau, X ., Attéré, S. A., Frenette, M., Lagüe, P. , Charette, S. J. (2016) Antibiotic resistance due to an unusual ColE1type replicon plasmid in Aeromonas salmonicida. Microbiology 162 :942953.
  • Maltais, R.? Trottier, A.? Barbeau, X.? Lagüe, P.? Perreault, M.? Thériault, J.F. ? Lin, S.X.? Poirier, D. (2015) Impact of structural modifications at positions 13, 16 and 17 of 16?(mcarbamoylbenzyl) estradiol on 17?hydroxysteroid dehydrogenase type 1 inhibition and estrogenic activity. J. Ster. Bioch. Mol. Biol. 161:2435.
  • Shayhidin, E.? Forcellini, E. ? Boulanger, M.C. ? Mahmut, A.? Dautrey, S.? Barbeau, X.? Lague, P .? Sévigny, J.? Paquin, J.F.? Mathieu, P. (2015). Quinazolin4piperidine sulfamides are specific inhibitors of human NPP1 and prevent pathologic mineralization of valve interstitial cells. British J. of Pharm. 172 (16) 41894199. (FRQNT Team Grant)
  • Blais, S. P.? Kornblatt, J. A.? Barbeau, X. ? Bonnaure, G.? Lagüe, P. ? Chênevert, R.? Lapointe, J. (2015). tRNAGlu increases the affinity of GlutamyltRNA synthetase for its inhibitor GlutamylSulfamoylAdenosine, an analogue of the aminoacylation reaction intermediate GlutamylAMP: mechanistic and evolutionary implications. PLoS One . 10 (4): e0121043. (FRQNT Team Grant)
  • Maltais, R.? Trottier, A.? Delhomme, A.? Barbeau, X. ? Lagüe, P .? Bouchard, J.E.? Poirier, D. (2015). Identification of fused 16?,17?oxazinoneestradiol derivatives as a new family of nonestrogenic 17?hydroxysteroid dehydrogenase type 1 inhibitor. Eur. J. Med. Chem . 93 : 47080.
  • Rheault, J.F.? Gagné, E.? Guertin, M.? Lamoureux, G.? Auger, M.? Lagüe, P. (2015). Molecular model of hemoglobin N from Mycobacterium tuberculosis bound to lipid bilayers: a combined spectroscopic and computational study. Biochemistry. 54 (11): 207384. (FRQNT Team Grant)
  • Wang, Y., X. Barbeau , Y. Yanga, A. Bilimoria, P. Lagüe , M. Couture and J. K.H. Tanga. (2015). Peroxidase Activity and Involvement in the Oxidative Stress Response of Roseobacter denitrificans Truncated Hemoglobin. PLoS One. 10 (2): e0117768.
  • Légaré, S.; Lagüe, P., (2014) "The influenza fusion peptide promotes lipid polar head intrusion through hydrogen bonding with phosphates and N-terminal membrane insertion depth", Proteins: Structure, Function, and Bioinformatics (sous presse) doi:10.1002/prot.24568
  • Maltais, R.; Ayan, D.; Trottier, A.; Barbeau, X.; Lagüe, P.; Bouchard, J.-E.; Poirier, D., (2014) "Discovery of a non-estrogenic irreversible inhibitor of 17?-hydroxysteroid dehydrogenase type 1 from 3-substituted-16?-(m-carbamoylbenzyl)-estradiol derivatives.", J. Med. Chem., 57(1), 204-22, doi: 10.1021/jm401639v
  • Dallaire-Dufresne, S.; Barbeau, X.; Sarty, D.; Tanaka, K.H.; Denoncourt, A.M.; Lagüe, P.; Reith, M.E.; Charette, S.J., (2013) "Aeromonas salmonicida Ati2 is an effector protein of the type three secretion system.", Microbiology, 159(Pt 9), 1937-45, doi: 10.1099/mic.0.067959-0
  • Lorin, A.; Noël, M.; Provencher, M.-È.; Turcotte, V.; Cardinal, S.; Lagüe, P.; Voyer, N.; Auger, M., (2012) "Determining the mode of action involved in the antimicrobial activity of synthetic peptides: a solid-state NMR and FTIR study.", Biophys. J., 103(7), 1470-9, doi: 10.1016/j.bpj.2012.08.055
  • Légaré, S.; Lagüe, P., (2012) "The influenza fusion peptide adopts a flexible flat V conformation in membranes.", Biophys. J., 102(10), 2270-8, doi: 10.1016/j.bpj.2012.04.003

Formation et expériences professionnelles

  • B. Sc. en biophysique, Université du Québec à Trois-Rivières (UQTR), 1993
  • M. Sc. en biophysique, Université du Québec à Trois-Rivières (UQTR), 1995
  • Ph. D. en chimie physique, Université de Montréal, 2001
 
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